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KMID : 1038620120300040182
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Radiation Oncology Journal
2012 Volume.30 No. 4 p.182 ~ p.188
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Re-irradiation of recurrent esophageal cancer after primary definitive radiotherapy
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Kim Young-Suk
Lee Chang-Geol
Kim Kyung-Hwan
Kim Tae-Hyung
Lee Joo-Hwan
Cho Yo-Na
Koom Woong-Sub
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Abstract
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Purpose: For recurrent esophageal cancer after primary definitive radiotherapy, no general treatment guidelines are available. We evaluated the toxicities and clinical outcomes of re-irradiation (re-RT) for recurrent esophageal cancer. Materials and Methods: We analyzed 10 patients with recurrent esophageal cancer treated with re-RT after primary definitive radiotherapy. The median time interval between primary radiotherapy and re-RT was 15.6 months (range, 4.8 to 36.4 months). The total dose of primary radiotherapy was a median of 50.4 Gy (range, 50.4 to 63.0 Gy). The total dose of re-RT was a median of 46.5 Gy (range, 44.0 to 50.4 Gy). Results: The median follow-up period was 4.9 months (range, 2.6 to 11.4 months). The tumor response at 3 months after the end of re-RT was complete response (n = 2), partial response (n = 1), stable disease (n = 2), and progressive disease (n = 5). Grade 5 tracheoesophageal fistula developed in three patients. The time interval between primary radiotherapy and re-RT was less than 12 months in two of these three patients. Late toxicities included grade 1 dysphagia (n = 1). Conclusion: Re-RT of recurrent esophageal cancer after primary radiotherapy can cause severe toxicity.
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KEYWORD
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Esophageal cancer, Neoplasm recurrence, Re-irradiation, Radiotherapy, Chemotherapy, Toxicity
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